Creatine is the most research-proven muscle-building supplement ever discovered. Time and time again, it has been shown in scientific studies to enhance high-intensity athletic performance, produce an increase in muscular force and power during high-intensity training and strength-dependant sports, and substantially increase the development of muscular size and strength resulting from resistance training.

All that sounds well and good, but do you really know what creatine actually does within a muscle cell that makes these marvelous things happen? You are about to find out.

Most all creatine in the body is found in skeletal muscle and exists in two forms, with 40% in the free creatine form, while the remaining majority of 60% exists in the phosphorylated form, called creatine phosphate (PCr), which is also known as phosphocreatine. Creatine works to increase muscle size and strength, which also translates to enhanced athletic performance for strength athletes, primarily through three mechanisms. One, creatine makes your muscles fuller (volumizing them) through enhanced uptake of intracellular water. Two, creatine supports enhanced muscle protein synthesis. Three, which is the primary mechanism when it comes to acting as a catalyst to produce long term increases in muscle and strength, creatine enhances the production of the high-energy compound adenosine triphosphate (ATP). ATP is a molecule that consists of adenosine combined with three phosphate (phosphorus) groups, and is the main energy source driving most biochemical reactions in the body for all cellular functions. Specifically, in its role in sustaining muscular activity, ATP is required for the shortening of actin and myosin filament cross-bridges required for muscles to actually contract.

Thus, during intense weight training, creatine phosphate (PCr) interacts directly with adenosine diphosphate (ADP) by donating one phosphate group to ADP, which then facilitates the resynthesis of the three-phosphate group structure, again forming adenosine triphosphate (ATP). This process transpires rapidly and allows the ATP pool to be turned over several dozen times during an all-out, maximal-effort weight training set. Thus, metabolic processes, such as that involved in muscular contraction that use ATP as an energy source, convert it back into its precursors. ATP is therefore continuously recycled. The human body, which on average contains 250g (8.8 oz) of ATP, turns over its own weight in ATP each day. This means that each ATP molecule is recycled 1000 to 1500 times during a single day!

Once creatine phosphate (PCr) has donated its phosphate group to adenosine diphosphate (ADP), it can then be resynthesized when the demand for ATP diminishes. This occurs through a reverse process in which ATP donates one phosphate group back to combine with creatine and form PCr.

From an ergogenic(performance-enhancing) perspective, optimizing the resynthesis of creatine phosphate (PCr) is one of the most important factors to sustain highly intense training. Creatine phosphate also has a role in helping buffer H+, which increases the cells capacity to attenuate the decline of pH levels during intense training and delays the onset of muscle fatigue.

So why supplement with creatine? The answer is quite simple, actually, and you should have already figured it out. The more creatine that is available within a muscle cell, the more phosphate can be stored in the form of creatine phosphate (PCr), because phosphate requires bonding with creatine to be stored as PCr. In other words, effective creatine supplementation produces a significant increase in PCr levels to continue to support the regeneration of adenosine triphosphate (ATP), which extends the duration of high-intensity weight training and strength-related athletics. Specifically, for bodybuilders, this means being able to lift more weight and perform more reps at any given weight, which stimulates a greater hypertrophic (muscle-building) response.

Truly effective creatine supplementation not only optimizes creatine availability and its utilization in the creatine phosphate (PCr) energy system, but also enhances the efficacy of creatine and the adenosine triphosphate and PCr energy systems, including by delaying the onset of muscular fatigue through intervention in intramuscular metabolism that results from muscular overload. Typical creatine supplementation simply does not do this....only AnavarŪ-PCr has a multi-faceted approach to accomplish this important muscle-building task.

AnavarŪ-PCr in a nutshell...

AnavarŪ-PCr goes way beyond simply enhancing the supply of numerous state-of-the-art creatine forms for storage in the body as creatine phosphate (PCr). AnavarŪ-PCr is an advanced creatine technology that also provides several sophisticated non-creatine compounds that enhance the efficacy of creatine, PCr, and the duration of uninterrupted adenosine triphosphate (ATP) supply by delaying the onset of muscular fatigue.

For bodybuilders, powerlifters, and strength athletes, the dual-prong ingredient formulation in AnavarŪ-PCr enhances the ability to perform more intense workouts by allowing for the handling of heavier weights and the ability to perform more reps at any given workload, which leads to substantial increases in the development of muscular size and strength.

The development of AnavarŪ-PCr, by Hi-Tech Pharmaceuticals, is a new model of human energy dynamics that will revolutionize bodybuilding and strength training through optimization of muscular contraction. AnavarŪ-PCr... thinking outside the creatine box.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, diagnose, or prevent any disease. This product should not be used in place of or as a substitute for recommendations by your healthcare professional. No clinical study has been performed on AnavarŪ PCr. These statements are based on the active ingredients: Creatine monohydrate, Creatine ethyl ester, Creatinol-O-Phosphate, Creatine Phosphate, Disodium Creatine Phosphate Tetrahydrate, Creatine AKG, Dicreatine Malate, Beta-Alanine, Inosine and L-Taurine.